Structure-based Design of Chimeric Influenza Hemagglutinins to Elicit Cross-group Immunity
Karla M. Castro, Reyhaneh Ayardulabi, Sarah Wehrle, Hongrui Cui, Sandrine Georgeon, Joseph H. Schmidt, Shuhao Xiao, Nishat Seraj, Wayne D. Harshbarger, Corey P. Mallett, Ventzislav B. Vassilev, Xavier Saelens, Bruno E. Correia
This paper designs chimeric influenza hemagglutinins that combine antigenic surfaces from different strains to elicit cross-group immunity and neutralize multiple strains.
bioRxiv · Dec 17, 2024 · PreprintBiochemistry