Disrupted microglial iron homeostasis in progressive multiple sclerosis
Jonathan D. Proto, Mindy Zhang, Sean K. Ryan, Xinting Yao, Yinyin Huang, Yi-Chien Chang, Michael R. Dufault, Emilie Christie, Anthony Chomyka, Jackie Saleh, José Sancho, Timothy R. Hammond, Bruce D. Trapp, Dimitry Ofengeim
This study identifies SPMS-enriched microglia subsets with disrupted iron homeostasis and oxidative stress using snRNA-seq and validates findings with histology and RNA-scope.
bioRxiv · May 9, 2021 · PreprintNeuroscience