Author

Michael R. Dufault

Sanofi (United States)ORCID 0000-0002-5124-1627Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:imaging· 1 Assay:snRNA-seq· 1

Frequent Co-Authors

Anthony Chomyka· 1 shared Bailin ZhangiD· 1 shared Bruce D. TrappiD· 1 shared Dimitry OfengeimiD· 1 shared Disha SoodiD· 1 shared Emilie ChristieiD· 1 shared Grace GaoiD· 1 shared Jackie Saleh· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperNeuroscience

Anthony Chomyka

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2 papers

Recent·Most cited

Unravelling neuronal and glial differences in ceramide composition, synthesis, and sensitivity to toxicity

John J. McInnis, Disha Sood, Lilu Guo, Michael R. Dufault, Mariana Gabriela García, Rachel Passaro, Grace Gao, Bailin Zhang, James C. Dodge

The paper shows human iPSC-derived neurons and glia differ in ceramide synthesis, composition, and toxicity sensitivity, linking these differences to inflammation, ER stress, and apoptosis.

Communications Biology · Nov 30, 2024Peer-reviewedNeuroscience

Disrupted microglial iron homeostasis in progressive multiple sclerosis

Jonathan D. Proto, Mindy Zhang, Sean K. Ryan, Xinting Yao, Yinyin Huang, Yi-Chien Chang, Michael R. Dufault, Emilie Christie, Anthony Chomyka, Jackie Saleh, José Sancho, Timothy R. Hammond, Bruce D. Trapp, Dimitry Ofengeim

This study identifies SPMS-enriched microglia subsets with disrupted iron homeostasis and oxidative stress using snRNA-seq and validates findings with histology and RNA-scope.

bioRxiv · May 9, 2021 · PreprintNeuroscience