Selective disruption of lipid peroxide homeostasis in intratumoral regulatory T cells by targeting FSP1 enhances cancer immunity
Jesse Garcia Castillo, Stephanie L. Silveria, Leo Schirokauer, Antoine Sauquet, Jessica Hung, Grace Jaworski, Joseph M. Hendricks, Hei Sook Sul, James A. Olzmann, Michel J.P. DuPage
This study shows targeting FSP1 in regulatory T cells disrupts their immunosuppression, enhancing anti-tumor immunity without causing autoimmunity.
Science Advances · Jan 23, 2026Peer-reviewedImmunology