ACOD1 regulates microglial arginine metabolism and inflammatory responses
Eleftheria Karadima, Canelif Yılmaz, Anupam Sinha, Georgia Fodelianaki, Sofia Dimothyra, Nikolaos Nirakis, Sofia Traikov, Nicola Zamboni, Ben Wielockx, Panayotis Verginis, Mirko Peitzsch, T Chavakis, Vasileia Ismini Alexaki
This study shows ACOD1 deficiency in microglia enhances inflammatory responses by altering arginine metabolism, specifically increasing argininosuccinate synthesis while reducing polyamine synthesis, dependent on ACLY.
Frontiers in Immunology · Mar 16, 2026Peer-reviewedImmunology