Peter Mirtschink

The paper uses droplet single-cell CRISPR screening to identify regulators of T cell-mediated target-cell killing and finds that mTORC1 modulation enhances cytotoxic activity.

The paper identifies HIF-1's role in regulating adrenal steroidogenesis through direct transcriptional control and miRNA biogenesis, revealing hypoxia's impact on miRNA-processing genes.

The paper uses human heart organoids to model mitochondrial disease and identifies a drug that improves mitochondrial function and tissue contractility.

This study shows that chronic glucocorticoid exposure, via HIF1 deficiency in adrenocortical cells, promotes HSPC expansion and myeloid bias while impairing B-cell development through GR-dependent mechanisms.

This study investigates how HIF1α regulates steroidogenesis under acute hypoxia using cell lines, ex vivo models, and mice, finding HIF1α-dependent miRNA regulation and translational control of steroidogenic enzymes.

This study shows that reduced endoglin in bone marrow endothelial cells causes vascular remodeling and hematopoietic changes, similar to those in hereditary hemorrhagic telangiectasia.

This study shows that HIF1α is essential for adipose tissue growth under normal conditions and in response to high-fat diets, by rechanneling metabolic intermediates into lipid synthesis.