Anja Krüger

HIF-1α coordinates adrenal steroidogenesis through direct transcriptional control and regulation of miRNA biogenesis

The paper identifies HIF-1's role in regulating adrenal steroidogenesis through direct transcriptional control and miRNA biogenesis, revealing hypoxia's impact on miRNA-processing genes.

HIF1α controls steroidogenesis under acute hypoxic stress

This study investigates how HIF1α regulates steroidogenesis under acute hypoxia using cell lines, ex vivo models, and mice, finding HIF1α-dependent miRNA regulation and translational control of steroidogenic enzymes.

Endoglin regulates the integrity of the bone marrow vasculature

This study shows that reduced endoglin in bone marrow endothelial cells causes vascular remodeling and hematopoietic changes, similar to those in hereditary hemorrhagic telangiectasia.

Hypoxia pathway proteins regulate the synthesis and release of epinephrine in the mouse adrenal gland

This study shows that PHD2-HIF2 pathway regulates epinephrine synthesis and release in mouse adrenal glands, linking hypoxia signaling to catecholamine production and systemic glucose levels.

HIF1α is an essential regulator of steroidogenesis in the adrenal gland

This study shows HIF1α is crucial for steroid hormone production in adrenal cells, with its absence increasing steroid levels and overexpression reducing them, affecting systemic health.