Rafal Bartoszewski

This study evaluates the combination of 5-FU with two triazoloacridinones, C-1305 and TRA-01AR, in CRC, finding that C-1305 shows greater antitumor activity while TRA-01AR has improved tolerability and vascular effects.

This study shows HIF1A-AS2 regulates the switch from HIF-1 to HIF-2 signaling in hypoxia by reducing HIF1A expression and increasing HIF-2 activity in endothelial cells.

The paper identifies HIF-1's role in regulating adrenal steroidogenesis through direct transcriptional control and miRNA biogenesis, revealing hypoxia's impact on miRNA-processing genes.