Author

Arielle Segal

Emory University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexa F. Iannitelli· 2 shared Anu KorukondaiD· 2 shared Bernard MulveyiD· 2 shared David WeinshenkeriD· 2 shared Joseph D. DoughertyiD· 2 shared Steven A. SloaniD· 2 shared Amanda Lea SharpeiD· 1 shared Daniel E. HuddlestoniD· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersNeuroscience

Alexa F. Iannitelli

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2 papers

Recent·Most cited

Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus

Leslie Hassanein, Bernard Mulvey, Harris E. Blankenship, Margaret Tish, Anu Korukonda, L. Cameron Liles, Amanda Lea Sharpe, Jean‐François Paré, Rosa M. Villalba, Xiangchuan Chen, Khan Hekmatyar, Jenny J. Yang, Daniel E. Huddleston, Seong Kang, Arielle Segal, , Alexa F. Iannitelli

This study shows that tyrosinase-induced neuromelanin accumulation in mouse locus coeruleus neurons causes hyperactivity, transcriptional changes, and degeneration, mimicking early stages of Alzheimer's and Parkinson's disease.

bioRxiv · Mar 7, 2023 · PreprintNeuroscience

The Neurotoxin DSP-4 Dysregulates the Locus Coeruleus-Norepinephrine System and Recapitulates Molecular and Behavioral Aspects of Prodromal Neurodegenerative Disease

Alexa F. Iannitelli, Michael A. Kelberman, Daniel J. Lustberg, Anu Korukonda, Katharine E McCann, Bernard Mulvey, Arielle Segal, Larry Cameron Liles, Steven A. Sloan, Joseph D. Dougherty, David Weinshenker

This study uses DSP-4 to model early LC-NE system changes in AD and PD, showing axon damage, neuroinflammation, and behavioral changes without LC cell death.

eNeuro · Dec 9, 2022Peer-reviewedNeuroscience