Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus
Leslie Hassanein, Bernard Mulvey, Harris E. Blankenship, Margaret Tish, Anu Korukonda, L. Cameron Liles, Amanda Lea Sharpe, Jean‐François Paré, Rosa M. Villalba, Xiangchuan Chen, Khan Hekmatyar, Jenny J. Yang, Daniel E. Huddleston, Seong Kang, Arielle Segal, , Alexa F. Iannitelli
This study shows that tyrosinase-induced neuromelanin accumulation in mouse locus coeruleus neurons causes hyperactivity, transcriptional changes, and degeneration, mimicking early stages of Alzheimer's and Parkinson's disease.
bioRxiv · Mar 7, 2023 · PreprintNeuroscience