Frequent transitions in self-assembly across the evolution of a central metabolic enzyme
Franziska L. Sendker, Tabea Schlotthauer, Christopher-Nils Mais, Yat Kei Lo, Mathias Girbig, Stefan Bohn, Thomas Heimerl, Daniel Schindler, Arielle Weinstein, Brian P. H. Metzger, Joseph W. Thornton, Arvind S. Pillai, Gert Bange, Jan M. Schuller, Georg K. A. Hochberg
The paper investigates the evolutionary dynamics of self-assembly in prokaryotic citrate synthases, finding frequent transitions between different assembly types without strong functional consequences.
Nature Communications · Dec 3, 2024Peer-reviewedEvolutionary Biology