Mathias Girbig

The paper studies the evolution of the RNA exosome, showing how an ancient active RNase evolved into a regulatory hub coordinating sequential RNase activities.

The paper investigates the evolutionary dynamics of self-assembly in prokaryotic citrate synthases, finding frequent transitions between different assembly types without strong functional consequences.

This study uses cryo-EM and smFRET to reveal structural and kinetic details of yeast TFIIIC engagement with tRNA promoter DNA motifs.

This study presents cryo-EM structures of human TFIIIC complex bound to a tRNA gene, revealing how it recognizes promoter motifs and facilitates Pol III activation.

The paper investigates RNAPIII transcription termination in budding yeast, showing T-tracts are necessary but not sufficient, and secondary structures and Sen1 helicase are important for termination.

The paper reports high-resolution cryo-EM structures of human RNA polymerase I, revealing structural features and disease-related mutations.

The paper presents cryo-EM structures of human RNA polymerase III in unbound and transcribing states, revealing structural insights into its function and disease associations.