Microglia dysfunction caused by the loss of Rhoa disrupts neuronal physiology and leads to neurodegeneration
Renato Socodato, Camila Cabral Portugal, Teresa Canedo, Artur Rodrigues, Tiago O. Almeida, Joana F. Henriques, Sandra Henriques Vaz, João Duarte Magalhães, Cátia M. Silva, Filipa I. Baptista, Renata L. Alves, Vanessa Coelho‐Santos, Ana Paula Silva, Roberto Paes‐de‐Carvalho, Ana Magalhães, , João Bettencourt Relvas
This study shows that loss of Rhoa in microglia causes neurodegeneration through Src-mediated Tnf production and excitotoxic glutamate secretion.
Cell Reports · Jun 1, 2020Peer-reviewedNeuroscience