Author

Cord Brakebusch

University of CopenhagenORCID 0000-0002-9342-1634Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

João Bettencourt RelvasiD· 3 shared Ana MagalhãesiD· 2 shared António Francisco AmbrósioiD· 2 shared Camila Cabral PortugaliD· 2 shared Filipa I. BaptistaiD· 2 shared Renato SocodatoiD· 2 shared Teresa CanedoiD· 2 shared Teresa SummavielleiD· 2 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersNeuroscience

João Bettencourt RelvasORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

SC2Spa: a deep learning based approach to map transcriptome to spatial origins at cellular resolution

Linbu Liao, Esha Madan, António M. Palma, Hyobin Kim, Amit Kumar, Praveen Bhoopathi, Robert A. Winn, Jose Trevino, Paul B. Fisher, Cord Brakebusch, Gahyun Kim, Junil Kim, Rajan Gogna, Kyoung‐Jae Won

SC2Spa maps single-cell RNA-seq data to spatial coordinates using deep learning, improving resolution for low-resolution spatial transcriptomics data and identifying spatially variable genes.

BMC Bioinformatics · Jun 2, 2025Peer-reviewedBioinformatics

Control of cortical cytoskeleton-membrane interaction by RhoA regulates peripheral nerve myelination

Ana Isabel Seixas, Miguel R. G. Morais, Cord Brakebusch, João Bettencourt Relvas

This study identifies RhoA's role in regulating Schwann cell myelination by controlling cytoskeleton-membrane interactions and biomechanical responses.

Progress in Neurobiology · Jun 12, 2023Peer-reviewedNeuroscience

Rac1 signaling in microglia is essential for synaptic proteome plasticity and experience-dependent cognitive performance

Renato Socodato, Tiago O. Almeida, Camila Cabral Portugal, Evelyn Cristina da Silva Santos, Joana Tedim-Moreira, Teresa Canedo, Filipa I. Baptista, Ana Magalhães, António Francisco Ambrósio, Cord Brakebusch, BORIS Y. RUBINSTEIN, Irina Sousa Moreira, Teresa Summavielle, Inês Mendes Pinto, João Bettencourt Relvas

This study shows Rac1 in microglia is crucial for synaptic proteome plasticity and cognitive performance through homeostatic regulation and synapse communication.

bioRxiv · Oct 18, 2021 · PreprintNeuroscience

Microglia dysfunction caused by the loss of Rhoa disrupts neuronal physiology and leads to neurodegeneration

Renato Socodato, Camila Cabral Portugal, Teresa Canedo, Artur Rodrigues, Tiago O. Almeida, Joana F. Henriques, Sandra Henriques Vaz, João Duarte Magalhães, Cátia M. Silva, Filipa I. Baptista, Renata L. Alves, Vanessa Coelho‐Santos, Ana Paula Silva, Roberto Paes‐de‐Carvalho, Ana Magalhães, , João Bettencourt Relvas

This study shows that loss of Rhoa in microglia causes neurodegeneration through Src-mediated Tnf production and excitotoxic glutamate secretion.

Cell Reports · Jun 1, 2020Peer-reviewedNeuroscience