Author

António Francisco Ambrósio

Association for Innovation and Biomedical Research on Light and ImageORCID 0000-0002-0477-1641Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Neuroscience· 2 Bioinformatics· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Ana MagalhãesiD· 2 shared Camila Cabral PortugaliD· 2 shared Cord BrakebuschiD· 2 shared Filipa I. BaptistaiD· 2 shared João Bettencourt RelvasiD· 2 shared Renato SocodatoiD· 2 shared Teresa CanedoiD· 2 shared Teresa SummavielleiD· 2 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersNeuroscience

Ana MagalhãesORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

NDR2 Kinase Regulate Microglial Metabolic Adaptation and Inflammatory Response: Critical Role in Glucose-Dependent Functional Plasticity

Beatriz Fazendeiro, Ivo F. Machado, Anabela Pinto Rolo, Paulo Rodrigues‐Santos, António Francisco Ambrósio, Paulo F. Santos, Hélène Léger

This study shows NDR2 kinase is essential for microglial metabolic adaptation to high glucose and inflammatory responses, with implications for diabetic retinopathy.

International Journal of Molecular Sciences · Oct 31, 2025Peer-reviewedImmunology

Rac1 signaling in microglia is essential for synaptic proteome plasticity and experience-dependent cognitive performance

Renato Socodato, Tiago O. Almeida, Camila Cabral Portugal, Evelyn Cristina da Silva Santos, Joana Tedim-Moreira, Teresa Canedo, Filipa I. Baptista, Ana Magalhães, António Francisco Ambrósio, Cord Brakebusch, BORIS Y. RUBINSTEIN, Irina Sousa Moreira, Teresa Summavielle, Inês Mendes Pinto, João Bettencourt Relvas

This study shows Rac1 in microglia is crucial for synaptic proteome plasticity and cognitive performance through homeostatic regulation and synapse communication.

bioRxiv · Oct 18, 2021 · PreprintNeuroscience

MorphData: Automating the data extraction process of morphological features of microglial cells in ImageJ

Ana Bela Campos, Sara Duarte‐Silva, António Francisco Ambrósio, Patrı́cia Maciel, Bruno Fernandes

MorphData automates the extraction of morphological features from microglial cells in ImageJ, reducing data collection time from weeks to minutes.

bioRxiv · Aug 5, 2021 · PreprintBioinformatics

Microglia dysfunction caused by the loss of Rhoa disrupts neuronal physiology and leads to neurodegeneration

Renato Socodato, Camila Cabral Portugal, Teresa Canedo, Artur Rodrigues, Tiago O. Almeida, Joana F. Henriques, Sandra Henriques Vaz, João Duarte Magalhães, Cátia M. Silva, Filipa I. Baptista, Renata L. Alves, Vanessa Coelho‐Santos, Ana Paula Silva, Roberto Paes‐de‐Carvalho, Ana Magalhães, , João Bettencourt Relvas

This study shows that loss of Rhoa in microglia causes neurodegeneration through Src-mediated Tnf production and excitotoxic glutamate secretion.

Cell Reports · Jun 1, 2020Peer-reviewedNeuroscience