APOBEC3-driven neoantigen-rich cancers co-opt 1q23.3 amplification for tumor-intrinsic immune cloaking
Dhanusha Yesudhas, Bilal A. Lone, Ecem Ünal, Arup Chakraborty, Ayşe Gökçe Keşküş, Jaimie Ryou, KM Butler, Tania Colon Aquino, Abbas Yousefi-Rad, Weiming Yang, Lisa M. Miller Jenkins, Raju R. Chelluri, Elias B. A. Chandran, Vladimir Valera Romero, Salah Boudjadi, , Abdul Rouf Banday
The paper identifies a tumor-intrinsic immune-cloaking mechanism in neoantigen-rich cancers driven by APOBEC3 mutagenesis and 1q23.3 amplification, showing NECTIN4's role in suppressing immune responses.
bioRxiv · Jul 4, 2026 · PreprintCancer Biology