Author

Damien Begue

Novartis (Switzerland)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Organism:non-human primate· 1 Assay:proteomics· 1

Frequent Co-Authors

Erik Ahrné· 2 shared Alexander N.R. WeberiD· 1 shared Alfred G. ZimmerliniD· 1 shared Amandine Rietsch· 1 shared Andreas HofmanniD· 1 shared Andreas Hofmann· 1 shared Andrew I. MorrisoniD· 1 shared Artiom CernijenkoiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

Erik Ahrné

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2 papers

Recent·Most cited

A cereblon (CRBN) molecular glue degrader of NIMA-related kinase 7 (NEK7) reveals a context-dependent role in NLRP3 inflammasome activation

Aude Sylvain, Natacha Stoehr, Fupeng Ma, Artiom Cernijenko, Martin Schröder, Maryam Khoshouei, Melanie Vogelsanger, Michel Schoenboerner, Ashley A. Burke, Pasupuleti Rao, Jonathan M. Solomon, Joshiawa Paulk, Lei Xu, Janet Dawson, Damien Begue, , Zuni I. Bassi

This paper identifies NK7-902, a CRBN molecular glue degrader of NEK7, showing partial inhibition of NLRP3 inflammasome activation in humans and full activity in mice, but only transient effects in non-human primates.

Cell chemical biology · Jul 1, 2025Peer-reviewedImmunology

A novel HERC4-dependent glue degrader targeting STING

Merve Mutlu, Isabel Schmidt, Andrew I. Morrison, Benedikt Goretzki, Felix Freuler, Damien Begue, Nicolas Pythoud, Erik Ahrné, Sandra Kapps, Susan Roest, Débora Bonenfant, Delphine Jeanpierre, Thi-Thanh-Thao Tran, Rob Maher, Shaojian An, , Danilo Guerini

This paper identifies AK59 as a molecular glue degrader for STING, showing HERC4 is the key E3 ligase for its degradation and demonstrating efficacy against STING mutations.

bioRxiv · Feb 8, 2023 · PreprintMolecular Biology