Anti-CD206 CAR T Cell Treatment Restores Fibrosis-Induced Loss of Dermal White Adipose Tissue
Chanhyuk Park, Asmaa O. Mohamed, Helen C. Jarnagin, Rajan Bhandari, Jason Gunn, Joana M. Murad-Mabaera, Noelle N. Kosarek, Fred Kolling, Owen Michael Wilkins, Yina H. Huang, Michael L. Whitfield, Patricia Ann Pioli
The paper demonstrates that anti-CD206 CAR T cells restore dermal white adipose tissue in systemic sclerosis by targeting CD206+ macrophages and reversing their effects on adipose-derived stem cells.
bioRxiv · Oct 16, 2025 · PreprintSynthetic Biology