Yina H. Huang

RAD: A Read-structure Agnostic Demultiplexer for Single-Cell Long-Read Sequencing and Analysis

RAD is a demultiplexer for single-cell long-read sequencing that improves speed and sensitivity over existing methods while supporting complex read structures.

Effects and mechanisms of monoclonal and polyclonal human antibodies in protection of humanized mice from HIV-1 challenge

This study evaluates how monoclonal and polyclonal human antibodies protect humanized mice from HIV-1 infection, showing that both neutralization and Fc-mediated effects contribute to protection.

Anti-CD206 CAR T Cell Treatment Restores Fibrosis-Induced Loss of Dermal White Adipose Tissue

The paper demonstrates that anti-CD206 CAR T cells restore dermal white adipose tissue in systemic sclerosis by targeting CD206+ macrophages and reversing their effects on adipose-derived stem cells.

Cancer therapy via neoepitope-specific monoclonal antibody cocktails

This paper demonstrates the use of neoepitope-specific monoclonal antibody cocktails to treat B16F10 melanoma by targeting unique tumor mutations, showing in vitro and in vivo efficacy.

Hierarchal single-cell lineage tracing reveals differential fate commitment of CD8 T-cell clones in response to acute infection.

This study uses single-cell lineage tracing to show that CD8 T-cell clones exhibit differential fate commitment during acute infection, with some clones adopting memory or effector biases over time.

Cell type-specific Interaction Analysis using Doublets in scRNA-seq (CIcADA)

CIcADA identifies and analyzes biological doublets in scRNA-seq data, finding they upregulate immune response genes in tumor datasets.