Owen Michael Wilkins

Multi-site Assessment of Methods for Cell Preservation Upstream of Single Cell RNA Sequencing

This study evaluates three cell preservation methods for scRNA-seq across multiple sites, showing concordant cell type results but platform-specific gene expression differences and better granulocyte retention with preservation methods.

Single-cell RNA sequencing of peripheral blood cells identifies transcriptomic signatures in Parkinson's disease

This study uses single-cell RNA sequencing to identify immune cell-specific gene expression signatures and sex differences in Parkinson's disease patients compared to healthy controls.

A ceramide synthase is important for filamentous fungal biofilm morphology and antifungal drug resistance

This study identifies a ceramide synthase, barA, as important for biofilm morphology and antifungal drug resistance in Aspergillus fumigatus.

Anti-CD206 CAR T Cell Treatment Restores Fibrosis-Induced Loss of Dermal White Adipose Tissue

The paper demonstrates that anti-CD206 CAR T cells restore dermal white adipose tissue in systemic sclerosis by targeting CD206+ macrophages and reversing their effects on adipose-derived stem cells.

Genome-wide abundance of 5-hydroxymethylcytosine in breast tissue reveals unique function in dynamic gene regulation and carcinogenesis

The paper maps 5-hydroxymethylcytosine (5hmC) distribution in normal breast tissue and links it to gene regulation and cancer prevention.