The paper shows that variable information across SNPs in GWAS data can lead to false colocalisation inferences and proposes a proportional colocalisation test to address this issue.

bioRxiv · Sep 8, 2025 · PreprintBioinformatics

Genetic regulation of the human plasma proteome in 54,306 UK Biobank participants

Benjamin B. Sun, Joshua Chiou, Matthew Traylor, Christian Benner, Yi‐Hsiang Hsu, Tom G. Richardson, Praveen Surendran, Anubha Mahajan, Chloe Robins, Steven G. Grinnell, Liping Hou, Erika M. Kvikstad, Oliver S. Burren, Jonathan Davitte, Kyle L. Ferber, , Christopher D. Whelan

The paper maps genetic associations with plasma proteins in 54,306 UK Biobank participants, identifying 10,248 new protein quantitative trait loci (pQTLs) and expanding the genetic architecture of the plasma proteome.

Nature · Oct 4, 2023Peer-reviewedGenetics

Brain DNA Methylation Patterns in CLDN5 Associated With Cognitive Decline

Anke Hüls, Chloe Robins, Karen N. Conneely, Rachel D. Edgar, Philip L. De Jager, David Alan Bennett, Aliza P. Wingo, Michael P. Epstein, Thomas S. Wingo

The paper identifies DNA methylation in the CLDN5 locus as associated with cognitive decline, independent of neuropathology, suggesting a role for the blood-brain barrier in cognitive trajectory.

Biological Psychiatry · Feb 1, 2022Peer-reviewedGenetics

Genetic control of the human brain proteome

Chloe Robins, Yue Liu, Wen Fan, Duc Minh Duong, Jacob Meigs, Nadia V. Harerimana, Ekaterina Sergeevna Gerasimov, Eric B. Dammer, David J. Cutler, Thomas G. Beach, Eric M. Reiman, Philip L. De Jager, David Alan Bennett, James J. Lah, Aliza P. Wingo, , Thomas S. Wingo

The paper identifies pQTLs for brain proteins and finds they differ from eQTLs, suggesting distinct genetic control of mRNA and protein abundance.

The American Journal of Human Genetics · Feb 10, 2021Peer-reviewedGenetics

Association between DNA Methylation Levels in Brain Tissue and Late-Life Depression in Community-Based Participants

Anke Hüls, Chloe Robins, Karen N. Conneely, Philip L. De Jager, David Alan Bennett, Michael P. Epstein, Thomas S. Wingo, Aliza P. Wingo

This study identifies DNA methylation loci associated with late-life depression in brain tissue, highlighting sex-specific differences.

Translational Psychiatry · Jul 30, 2020Peer-reviewedGenetic & Genomic Medicine