Kynurenic acid inflammatory signaling expands in primates and impairs prefrontal cortical cognition
Shengtao Yang, Dibyadeep Datta, Fenna M. Krienen, Emi Ling, Elizabeth Woo, Athena May, George Anderson, Veronica C. Galvin, Guillermo González‐Burgos, David A. Lewis, Steven A. McCarroll, Amy F.T. Arnsten, Min Wang
This study shows that kynurenic acid (KYNA) and its enzyme KAT II expand in primate dlPFC, impairing cognitive functions by affecting NMDA and nic-7Rs, and suggests targeting KYNA as a therapeutic approach for neuroinflammatory disorders.
bioRxiv · Jun 13, 2024 · PreprintNeuroscience