Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis
Mollie K. Huber, Adrienne E. Widener, Alexandra E. Cuaycal, Dylan Smurlick, Elizabeth Ashley Butterworth, Nataliya I. Lenchik, Jing Chen, Maria L. Beery, Helmut Hiller, Ellen Verney, Irina Kusmartseva, Marjan Slak Rupnik, Martha Campbell‐Thompson, Ivan Gerling, Mark A. Atkinson, , Edward A. Phelps
This study shows that beta cell dysfunction occurs in type 1 diabetes independently of T cell infiltration, using human pancreas tissue slices from recently diagnosed patients.
Cell Reports · Aug 27, 2025Peer-reviewedPhysiology