The paper reveals that GABA secretion from pancreatic beta cells occurs via the LRRC8A/D VRAC channel and is coordinated with calcium influx and depolarization, not vesicular release or insulin secretion.

Molecular Metabolism · Sep 25, 2026Peer-reviewedPhysiology

Molecular requirements of chromogranin B for the long-sought anion shunter of regulated secretion

Gaya Prasad Yadav, Mani Annamalai, D. Walker Hagan, Lina Cui, Clayton E. Mathews, Qiu‐Xing Jiang

This study identifies chromogranin B (CHGB) as the anion shunt conductance in secretory granules, showing its essential role in granule acidification and regulated secretion.

International Journal of Biological Macromolecules · Mar 17, 2025Peer-reviewedCell Biology

Neuronal growth regulator 1 (NEGR1) promotes synaptic targeting of glutamic acid decarboxylase 65 (GAD65)

Rui Ping Amanda Tan, Irina Kozlova, Feifei Su, Saroj Kumar Sah, Ryan Keable, D. Walker Hagan, Sonia Bustamante, Ximing Du, Brenna Osborne, Nigel A. Turner, Kelly J. Clemens, Denovan P. Begg, Edward A. Phelps, Hongyuan Yang, Iryna Leshchyns’ka, Vladimir Sytnyk

This study shows NEGR1 promotes synaptic targeting of GAD65, affecting GABAergic signaling and feeding behavior in mice.

bioRxiv · Feb 8, 2022 · PreprintNeuroscience