Constricted cell migration causes nuclear lamina damage, DNA breaks, and squeeze-out of repair factors
Jerome Irianto, Charlotte R. Pfeifer, Yuntao Xia, Avathamsa Athirasala, Irena L. Ivanovska, Roger A. Greenberg, Dennis E. Discher
The paper shows that constricted cell migration in stiff tissues causes nuclear lamina damage, DNA breaks, and loss of repair factors, leading to genomic instability.
bioRxiv · Dec 30, 2015 · PreprintCell Biology