Author

Roger A. Greenberg

Primary ORCID profile (0000-0003-1326-8981 · 11 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Roger A. GreenbergiD11 papers · University of Pennsylvania

Biology Disciplines

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Cell Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Charlotte R. PfeiferiD· 3 shared Dennis E. DischeriD· 3 shared Jerome IriantoiD· 3 shared Yuntao XiaiD· 3 shared Irena L. Ivanovska· 2 shared Andrea J. Liu· 1 shared Avathamsa Athirasala· 1 shared Dazhen Liu· 1 shared

Activity by Year

2015-2017 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersCell Biology

Charlotte R. PfeiferORCID

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Author profile →

3 papers

Recent·Most cited

Cell cycle repression and DNA repair defects follow constricted migration

Charlotte R. Pfeifer, Yuntao Xia, Kuangzheng Zhu, Dazhen Liu, Jerome Irianto, Shane Harding, Roger A. Greenberg, Dennis E. Discher

The paper shows that constricted migration causes nuclear rupture and DNA damage, which are linked to cell cycle repression and DNA repair defects in cancer cells.

bioRxiv · Dec 29, 2017 · PreprintBiophysics

DNA damage in 3D constricted migration or after lamin-A depletion in 2D: shared mechanisms of repair factor mis-localization under nuclear stress

Yuntao Xia, Jerome Irianto, Charlotte R. Pfeifer, Jiazheng Ji, Irena L. Ivanovska, Manu Tewari, Rachel R. Bennett, Shane M. Harding, Andrea J. Liu, Roger A. Greenberg, Dennis E. Discher

bioRxiv · Dec 28, 2016 · PreprintCell Biology

Constricted cell migration causes nuclear lamina damage, DNA breaks, and squeeze-out of repair factors

Jerome Irianto, Charlotte R. Pfeifer, Yuntao Xia, Avathamsa Athirasala, Irena L. Ivanovska, Roger A. Greenberg, Dennis E. Discher

The paper shows that constricted cell migration in stiff tissues causes nuclear lamina damage, DNA breaks, and loss of repair factors, leading to genomic instability.

bioRxiv · Dec 30, 2015 · PreprintCell Biology