Early Antibody-Mediated Immunity to Tuberculosis in Mice Requires NLRP3
Rania Bouzeyen, Nyaradzai Sithole, Avia Watson, Lilach Abramovitz, Katya Rakayev, Adam Fillion, Tessa Dickson, Paul A. MacAry, Patricia A. Darrah, Robert A. Seder, Natalia Tarnovitski Freund, Babak Javid
This study shows that antibodies against Mtb enhance immunity via NLRP3 inflammasome activation in mice, independent of Fc receptors, and this mechanism applies to polyclonal sera in rhesus macaques.
bioRxiv · Jul 18, 2025 · PreprintImmunology