Author

Patricia A. Darrah

National Institutes of HealthORCID 0000-0002-0035-2802Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:non-human primate· 3 Assay:proteomics· 3 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Robert A. SederiD· 4 shared Charles A. ScangaiD· 3 shared Mario RoedereriD· 3 shared Henry Jacob BorishiD· 2 shared Jaime A. TomkoiD· 2 shared JoAnne L. FlynniD· 2 shared Mark A. RodgersiD· 2 shared Michael C. ChaoiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

Robert A. SederORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Early Antibody-Mediated Immunity to Tuberculosis in Mice Requires NLRP3

Rania Bouzeyen, Nyaradzai Sithole, Avia Watson, Lilach Abramovitz, Katya Rakayev, Adam Fillion, Tessa Dickson, Paul A. MacAry, Patricia A. Darrah, Robert A. Seder, Natalia Tarnovitski Freund, Babak Javid

This study shows that antibodies against Mtb enhance immunity via NLRP3 inflammasome activation in mice, independent of Fc receptors, and this mechanism applies to polyclonal sera in rhesus macaques.

bioRxiv · Jul 18, 2025 · PreprintImmunology

CD4 T cells and CD8α+ lymphocytes are necessary for intravenous BCG-induced protection against tuberculosis in macaques

Andrew W. Simonson, Joseph John Zeppa, Allison N. Bucşan, Michael C. Chao, Supriya Pokkali, Forrest F. Hopkins, Michael R. Chase, Andrew J. Vickers, Matthew S. Sutton, Caylin G. Winchell, Amy J. Myers, Cassaundra L. Ameel, Ryan J. Kelly, Ben Krouse, Luke E. Hood, , JoAnne L. Flynn

The paper shows that CD4 T cells and innate CD8+ lymphocytes are essential for IV BCG-induced protection against tuberculosis in macaques.

The Journal of Experimental Medicine · Feb 6, 2025Peer-reviewedImmunology

Humoral correlate of vaccine-mediated protection from tuberculosis identified in humans and non-human primates

Natasha S. Kelkar, Nicholas C. Curtis, Urjeet S. Khanwalkar, Olivia Palmer, Timothy Lahey, Wendy Wieland‐Alter, Jason E. Stout, Erica C. Larson, Solomon Jauro, Charles A. Scanga, Patricia A. Darrah, Mario Roederer, Robert A. Seder, C. Fordham von Reyn, Jiwon Lee, Margaret E. Ackerman

The paper identifies a humoral correlate of protection against tuberculosis in humans and non-human primates, showing cross-species and vaccine regimen consistency.

bioRxiv · Dec 5, 2024 · PreprintImmunology

Markov Field network integration of multi-modal data predicts effects of immune system perturbations on intravenous BCG vaccination in macaques

Shu Wang, Amy J. Myers, Edward B. Irvine, Chuangqi Wang, Pauline A Maiello, Mark Rodgers, Jaime A. Tomko, Kara B. Kracinovsky, Henry Jacob Borish, Michael C. Chao, Douaa Mugahid, Patricia A. Darrah, Robert A. Seder, Mario Roederer, Charles A. Scanga, , Douglas A. Lauffenburger

The paper uses Markov Fields to integrate multi-modal immune data from vaccinated macaques, identifying critical immune interactions and predicting perturbation effects.

Cell Systems · Nov 5, 2024Peer-reviewedSystems Biology