Acetoacetate suppresses colon cancer via an MR1-MAIT axis
Slater L. Clay, Geniver El Tekle, Edrees H. Rashan, Diogo Fonseca‐Pereira, Yern‐Hyerk Shin, Natalia Andreeva, Geicho Nakatsu, Ayesha F. Lobo, Sway P. Chen, Sena Bae, Monia Michaud, Jonathan N. Glickman, Jon Clardy, Matthew G. Vander Heiden, Wendy S. Garrett
This study shows that acetoacetate suppresses colon cancer by expanding and activating MAIT cells via the MR1 receptor, offering a potential immunotherapy approach.
bioRxiv · Oct 29, 2025 · PreprintImmunology