Author

Wendy S. Garrett

Broad InstituteORCID 0000-0002-5092-0150Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Sena Bae· 3 shared Diogo Fonseca‐PereiraiD· 2 shared Geniver El TekleiD· 2 shared Jon ClardyiD· 2 shared Jonathan N. GlickmaniD· 2 shared Monia Michaud· 2 shared Natalia Andreeva· 2 shared Slater L. ClayiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Sena Bae

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Microbial-associated acylated putrescines as immunomodulatory molecules in inflammatory bowel diseases

Sena Bae, Julián Ávila-Pacheco, Slater L. Clay, Sunghee Bang, Milcah C. Scott, Natalia Andreeva, Monia Michaud, Diogo Fonseca‐Pereira, Eunyoung Chun, Y. Grace Cao, Yancong Zhang, Amrisha Bhosle, Rosa M. Perez, Gleb Pishchany, Hera C. Vlamakis, , Wendy S. Garrett

The paper identifies N-acyl putrescines, particularly NOP, as immunomodulatory metabolites produced by gut microbiota that suppress inflammation in IBD models.

bioRxiv · Aug 25, 2026 · PreprintImmunology

Western-style diet-induced microbial shifts and inflammation reprogram c-Kit⁺ secretory cells into targets for tumor initiation

Sara Silva, Paola Procopio, Valeriya V. Zinina, Solveig Turss, Rafael R. Segura Muñoz, Seyram Segbefia, Sena Bae, Lior Lobel, Luigi L. Nardella, Andrea Sacchetti, Rosalie Joosten, Coen Linn, Susanna Plugge, Mathijs P. Verhagen, Fatma Aktuna, , Mark R. Schmitt

This study shows that a Western-style diet reprograms c-Kit⁺ secretory cells into tumor-initiating cells via microbial shifts and inflammation.

bioRxiv · Jul 19, 2026 · PreprintCell Biology

Acetoacetate suppresses colon cancer via an MR1-MAIT axis

Slater L. Clay, Geniver El Tekle, Edrees H. Rashan, Diogo Fonseca‐Pereira, Yern‐Hyerk Shin, Natalia Andreeva, Geicho Nakatsu, Ayesha F. Lobo, Sway P. Chen, Sena Bae, Monia Michaud, Jonathan N. Glickman, Jon Clardy, Matthew G. Vander Heiden, Wendy S. Garrett

This study shows that acetoacetate suppresses colon cancer by expanding and activating MAIT cells via the MR1 receptor, offering a potential immunotherapy approach.

bioRxiv · Oct 29, 2025 · PreprintImmunology