Author

Sway P. Chen

Harvard UniversityORCID 0000-0002-1722-2473Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Organism:mouse· 2 Organism:bacteria (other)· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Diogo Fonseca‐PereiraiD· 2 shared Geniver El TekleiD· 2 shared Harris H. WangiD· 2 shared Jon ClardyiD· 2 shared Jonathan N. GlickmaniD· 2 shared Monia Michaud· 2 shared Natalia Andreeva· 2 shared Sena Bae· 2 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersImmunology

Diogo Fonseca‐PereiraORCID

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4 papers

Recent·Most cited

Microbial-associated acylated putrescines as immunomodulatory molecules in inflammatory bowel diseases

Sena Bae, Julián Ávila-Pacheco, Slater L. Clay, Sunghee Bang, Milcah C. Scott, Natalia Andreeva, Monia Michaud, Diogo Fonseca‐Pereira, Eunyoung Chun, Y. Grace Cao, Yancong Zhang, Amrisha Bhosle, Rosa M. Perez, Gleb Pishchany, Hera C. Vlamakis, , Wendy S. Garrett

The paper identifies N-acyl putrescines, particularly NOP, as immunomodulatory metabolites produced by gut microbiota that suppress inflammation in IBD models.

bioRxiv · Aug 25, 2026 · PreprintImmunology

Acetoacetate suppresses colon cancer via an MR1-MAIT axis

Slater L. Clay, Geniver El Tekle, Edrees H. Rashan, Diogo Fonseca‐Pereira, Yern‐Hyerk Shin, Natalia Andreeva, Geicho Nakatsu, Ayesha F. Lobo, Sway P. Chen, Sena Bae, Monia Michaud, Jonathan N. Glickman, Jon Clardy, Matthew G. Vander Heiden, Wendy S. Garrett

This study shows that acetoacetate suppresses colon cancer by expanding and activating MAIT cells via the MR1 receptor, offering a potential immunotherapy approach.

bioRxiv · Oct 29, 2025 · PreprintImmunology

An Engineered Cas-Transposon System for Programmable and Precise DNA Transpositions

Sway P. Chen, Harris H. Wang

This paper introduces a Cas-Transposon system for programmable DNA insertion, showing it increases transposition efficiency by over 300-fold at targeted sites.

The CRISPR Journal · Dec 1, 2019Peer-reviewedSynthetic Biology

Multiplex transcriptional characterizations across diverse and hybrid bacterial cell-free expression systems

Sung Sun Yim, Nathan I Johns, Jimin Park, Antonio L. C. Gomes, Ross M. McBee, Miles Richardson, Carlotta Ronda, Sway P. Chen, David Garenne, Vincent Noireaux, Harris H. Wang

The paper introduces DRAFTS, a method for multiplexed transcriptional measurement in cell-free systems, and shows functional differences in gene expression across bacterial species and hybrid lysates.

Molecular Systems Biology · Aug 1, 2019Peer-reviewedSynthetic Biology