Jon Clardy

The paper identifies N-acyl putrescines, particularly NOP, as immunomodulatory metabolites produced by gut microbiota that suppress inflammation in IBD models.

This study identifies an ancient sensory receptor family in choanoflagellates that detects bacterial prey, revealing ancestral features of animal sensation before multicellularity.

This study identifies aerocavin as a potent and specific antibiotic against Neisseria, showing it inhibits bacterial RNA polymerase and has low resistance evolution rates in N. gonorrhoeae.

This study examines metabolomic diversity in Amazonian Pseudonocardia bacteria, showing that ecological interactions and local adaptation drive chemical variation rather than phylogeny.

This study identifies Blautia wexlerae's role in converting dietary fats into bioactive metabolites that enhance gut hormone secretion and improve metabolic health in mice and humans.

This paper identifies 4,5-dihydroxyhexanoic acid as a biomarker for mitochondrial disease severity and links it to GABA metabolism.

This study shows that acetoacetate suppresses colon cancer by expanding and activating MAIT cells via the MR1 receptor, offering a potential immunotherapy approach.

This study analyzes the gut microbiome of Passalid beetles, revealing high cellulolytic potential and significant methane production comparable to termites.

This study shows that microbiomes on ecological surfaces activate octopus chemotactile receptors to guide behavior through distinct molecular signals.

This study identifies beta-carboline compounds produced by vaginal lactobacilli that reduce inflammation by suppressing immune signaling pathways and demonstrate therapeutic potential in a mouse model.

This study identifies a new intergenerational communication pathway in C. elegans linking sensory perception to maternal provisioning through FMRF-like peptides.

The paper analyzes genetic diversity and biosynthetic potential in Pseudonocardia bacteria associated with fungus-growing ants across a 20km transect, revealing geographic and phylogenetic patterns of microbial diversity.

The paper demonstrates that mammalian cells can produce novel steroids using steroid-modifying enzymes, identifying new hydroxylation sites and potential applications for drug candidate testing.