Bone innervation and vascularization regulated by osteoclasts contribute to refractive pain-related behavior in the collagen antibody-induced arthritis model
Resti Rudjito, Nilesh M. Agalave, Alex Bersellini Farinotti, Azar Baharpoor, A Martínez-Martínez, Enriqueta Muñoz‐Islas, Preety Panwar, Dieter Brömme, Julie Barbier, Fabien Marchand, Patrick Mehlen, Thomas Levin Andersen, Juan Miguel Jiménez‐Andrade, Camilla I. Svensson
This study shows osteoclasts contribute to pain in arthritis by affecting bone vascularization and innervation, and inhibitors can reverse this pain.
bioRxiv · Apr 19, 2021 · PreprintNeuroscience