Emerson Krock

A novel method to sort and enrich sensory neurons

This study identifies surface markers for isolating sensory neurons and develops a FACS panel for their enrichment without transgenic mice, validated by microscopy and scRNA-seq.

Tissue-to-Analysis Framework Enables Multiscale Mapping of the Architectural and Cellular Organization in the Human Dorsal Root Ganglion

The paper develops a tissue-to-analysis framework to map the cellular and architectural organization of human dorsal root ganglia using transcriptomic and protein data.

Neutrophil-neuronal crosstalk drives arthritis-induced pain

This study identifies SEMA4D and OSM as mediators of neutrophil-neuron communication in arthritis-induced pain, showing their role in neuronal sprouting and hypersensitivity.

Gut microbiota promotes pain in fibromyalgia

This study shows that gut microbiota from fibromyalgia patients causes pain in mice, and transferring healthy microbiota alleviates symptoms in humans.

Fibromyalgia patients have altered lipid concentrations associated with disease symptom severity and anti-satellite glial cell IgG antibodies

The paper examines lipid metabolism and anti-satellite glial cell IgG antibodies in fibromyalgia patients, finding associations between lipid concentrations, symptom severity, and autoantibody levels.

Microbially produced bile acids are associated with high levels of IgG autoantibodies and worse mental wellbeingin fibromyalgia subjects

The paper examines bile acid and short-chain fatty acid levels in fibromyalgia patients and healthy controls, finding higher bile acid levels in patients and associations with autoantibodies and mental well-being.

Fibromyalgia patients with high levels of anti-satellite glia cell IgG antibodies present with more severe symptoms

This study finds that fibromyalgia patients with higher anti-satellite glia cell IgG antibodies have more severe symptoms, suggesting these antibodies may contribute to disease severity.

Passive transfer of fibromyalgia pain from patients to mice.

This study shows that fibromyalgia pain is caused by IgG autoantibodies that sensitize sensory neurons in mice, suggesting potential treatment through reducing IgG levels.