Pharmacological and genetic activation of cAMP synthesis disrupts cholesterol utilization in Mycobacterium tuberculosis
K. M. Wilburn, C. R. Montague, B. Qin, A. K. Woods, M. S. Love, C. W. McNamara, P. G. Schultz, T. L. Southard, L. Huang, H. M. Petrassi, B. C. VanderVen
This paper identifies a small molecule agonist of Mtb adenylyl cyclase Rv1625c that inhibits cholesterol utilization and disrupts Mtb pathogenesis in mice.
bioRxiv · Aug 3, 2021Microbiology