Author

C. W. McNamara

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 5 Approach:experimental assay· 4 Organism:human· 3 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Assay:proteomics· 1

Frequent Co-Authors

P. G. Schultz· 3 shared A. K. Chatterjee· 2 shared A. K. Gupta· 2 shared A. K. Woods· 2 shared E. Chen· 2 shared M. A. Bakowski· 2 shared M. G. Kirkpatrick· 2 shared M. S. Love· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersMicrobiology

P. G. Schultz

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cryptosporidium Life Cycle Small Molecule Probing Implicates Translational Repression And An Apetala 2 Transcription Factor In Sexual Differentiation

M. M. Hasan, E. B. Mattice, J. E. Teixeira, R. S. Jumani, E. E. Stebbins, C. E. Klopfer, S. E. Franco, M. S. Love, C. W. McNamara, C. D. Huston

This study identifies small-molecule compounds that modulate sexual differentiation in Cryptosporidium using a multi-readout imaging assay and confirms translational repression and an AP2 transcription factor's role in this process.

bioRxiv · Dec 18, 2023 · PreprintMicrobiology

Discovery of CMX990: A Potent SARS-CoV-2 3CL Protease Inhibitor Bearing a Novel Covalent Warhead

N. G. R. D. Elshan, K. C. Wolff, L. Riva, A. K. Woods, G. Grabovyi, K. Wilson, A. Rahimi, J. Pedroarena, S. Ghorai, A. K. Gupta, A. Nazarian, F. Weiss, Y. Liu, W. Mazumdar, L. Song, , A. K. Chatterjee

This paper introduces CMX990, a potent SARS-CoV-2 3CL protease inhibitor with improved potency and clearance compared to nirmatrelvir, advancing to Phase 1 clinical trials.

bioRxiv · Oct 24, 2023Microbiology

Pharmacological and genetic activation of cAMP synthesis disrupts cholesterol utilization in Mycobacterium tuberculosis

K. M. Wilburn, C. R. Montague, B. Qin, A. K. Woods, M. S. Love, C. W. McNamara, P. G. Schultz, T. L. Southard, L. Huang, H. M. Petrassi, B. C. VanderVen

This paper identifies a small molecule agonist of Mtb adenylyl cyclase Rv1625c that inhibits cholesterol utilization and disrupts Mtb pathogenesis in mice.

bioRxiv · Aug 3, 2021Microbiology

Oral drug repositioning candidates and synergistic remdesivir combinations for the prophylaxis and treatment of COVID-19

M. A. Bakowski, N. Beutler, E. Chen, T.-T. H. Nguyen, M. G. Kirkpatrick, M. Parren, L. Yang, J. Ricketts, A. K. Gupta, M. V. Hull, P. G. Schultz, D. R. Burton, A. K. Chatterjee, C. W. McNamara, T. F. Rogers

The paper identifies 66 compounds that inhibit SARS-CoV-2 replication and 24 that synergize with remdesivir, suggesting potential oral drug repositioning candidates for COVID-19.

Nature Communications · Jun 3, 2021Peer-reviewedMicrobiology

High-throughput screening of the ReFRAME library identifies potential drug repurposing candidates for Trypanosoma cruzi

J. A. Bernatchez, E. Chen, M. V. Hull, C. W. McNamara, J. H. McKerrow, J. L. Siqueira-Neto

The paper screens 12,000 compounds from the ReFRAME library against Trypanosoma cruzi, identifying 7 with potent in vitro activity and therapeutic index ≥10.

bioRxiv · Dec 11, 2019Microbiology