Mutations in TAC1B: a novel genetic determinant of clinical fluconazole resistance in C. auris
J. M. Rybak, J. F. Munoz, K. S. Barker, J. Parker, B. D. Esquivel, E. L. Berkow, S. R. Lockhart, L. Gade, G. E. Palmer, T. C. White, S. L. Kelly, C. A. Cuomo, P. D. Rogers
This paper identifies mutations in TAC1B as a novel genetic determinant of clinical fluconazole resistance in C. auris, showing their contribution to resistance through increased CDR1 expression and functional validation.
bioRxiv · Feb 18, 2020Microbiology