Author

J. M. Rybak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Organism:C. elegans· 3 Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

C. A. Cuomo· 2 shared J. F. Munoz· 2 shared K. S. Barker· 2 shared P. D. Rogers· 2 shared S. L. Kelly· 2 shared A. Abdullah· 1 shared B. D. Esquivel· 1 shared C. F. Ancajas· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMicrobiology

C. A. Cuomo

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Author profile →

3 papers

Recent·Most cited

The small molecule CBR-5884 inhibits the Candida albicans phosphatidylserine synthase

Y. Zhou, G. A. Phelps, M. M. Mangrum, J. McLeish, E. K. Phillips, J. Lou, C. F. Ancajas, J. M. Rybak, P. M. Oelkers, M. D. Best, R. Lee, T. B. B. Reynolds

The paper identifies CBR-5884 as a potent inhibitor of Candida albicans Cho1, showing fungistatic effects and disrupting in vivo Cho1 function.

bioRxiv · Nov 1, 2023 · PreprintMicrobiology

In vivo emergence of high-level resistance during treatment reveals the first identified mechanism of amphotericin B resistance in Candida auris

J. M. Rybak, K. S. Barker, J. F. Munoz, J. E. Parker, S. Ahmad, E. Mokaddas, A. Abdullah, R. S. Elhagracy, S. L. Kelly, C. A. Cuomo, P. D. Rogers

The paper identifies a mutation in the ERG6 gene as the first mechanism of amphotericin B resistance in Candida auris, observed during in vivo treatment.

bioRxiv · Oct 8, 2021Microbiology

Mutations in TAC1B: a novel genetic determinant of clinical fluconazole resistance in C. auris

J. M. Rybak, J. F. Munoz, K. S. Barker, J. Parker, B. D. Esquivel, E. L. Berkow, S. R. Lockhart, L. Gade, G. E. Palmer, T. C. White, S. L. Kelly, C. A. Cuomo, P. D. Rogers

This paper identifies mutations in TAC1B as a novel genetic determinant of clinical fluconazole resistance in C. auris, showing their contribution to resistance through increased CDR1 expression and functional validation.

bioRxiv · Feb 18, 2020Microbiology