Author
S. L. Kelly
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2019-2023 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 22 mutual co-author links7 papers
Recent·Most cited
The sterol C-24 methyltransferase encoding gene, erg6, is essential for viability of Aspergillus species.
J. Xie, J. Rybak, A. Martin-Vicente, X. Guruceaga, H. Thorn, A. Nywening, W. Ge, J. Parker, S. L. Kelly, D. Rogers, J. Fortwendel
This paper identifies Erg6 as an essential gene for viability in Aspergillus species and shows its importance in fungal infection models.
bioRxiv · Aug 8, 2023 · PreprintMicrobiology
Purification of synchronized E. coli transcription elongation complexes by reversible immobilization on magnetic beads
S. L. Kelly, C. E. Szyjka, E. J. Strobel
This paper develops a method to purify synchronized E. coli transcription elongation complexes using a custom leader sequence, enabling high-purity, active, and synchronous TECs for RNA assays.
bioRxiv · Jan 10, 2022Biochemistry
In vivo emergence of high-level resistance during treatment reveals the first identified mechanism of amphotericin B resistance in Candida auris
J. M. Rybak, K. S. Barker, J. F. Munoz, J. E. Parker, S. Ahmad, E. Mokaddas, A. Abdullah, R. S. Elhagracy, S. L. Kelly, C. A. Cuomo, P. D. Rogers
The paper identifies a mutation in the ERG6 gene as the first mechanism of amphotericin B resistance in Candida auris, observed during in vivo treatment.
bioRxiv · Oct 8, 2021Microbiology
Loss-of-function ROX1 mutations suppress the fluconazole susceptibility of upc2AΔ mutation in Candida glabrata, implicating additional positive regulators of ergosterol biosynthesis
T. L. Ollinger, B. Vu, D. Murante, J. Parker, L. Simonicova, L. A. Doorley, M. A. Stamnes, S. L. Kelly, P. D. Rogers, W. S. Moye-Rowley, D. J. Krysan
The paper identifies ROX1 as a negative regulator of ergosterol biosynthesis genes in C. glabrata and shows that its loss-of-function suppresses fluconazole hypersusceptibility in upc2AΔ mutants.
bioRxiv · Oct 7, 2021 · PreprintMicrobiology
Mutations in TAC1B: a novel genetic determinant of clinical fluconazole resistance in C. auris
J. M. Rybak, J. F. Munoz, K. S. Barker, J. Parker, B. D. Esquivel, E. L. Berkow, S. R. Lockhart, L. Gade, G. E. Palmer, T. C. White, S. L. Kelly, C. A. Cuomo, P. D. Rogers
This paper identifies mutations in TAC1B as a novel genetic determinant of clinical fluconazole resistance in C. auris, showing their contribution to resistance through increased CDR1 expression and functional validation.
bioRxiv · Feb 18, 2020Microbiology
Comparative genomics for the elucidation of multidrug resistance (MDR) in Candida lusitaniae
A. Kannan, S. Asner, E. Trachsel, S. L. Kelly, J. Parker, D. Sanglard
This paper identifies six non-synonymous SNPs associated with multidrug resistance in Candida lusitaniae through comparative genomics and functional validation.
bioRxiv · Sep 24, 2019Microbiology