Author

J. Stroobants

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:drug response / drug discovery· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 2 Organism:virus· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

K. Vermeire· 8 shared P. Maes· 7 shared B. Provinciael· 5 shared A. Camps· 4 shared E. Vanhulle· 4 shared B. Vanmechelen· 3 shared S. Noppen· 3 shared A. Stevaert· 2 shared

Activity by Year

2021-2022 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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8 shared papersMicrobiology

K. Vermeire

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Cellular electrical impedance to profile SARS-CoV-2 fusion inhibitors and to assess the fusogenic potential of spike mutants

E. Vanhulle, J. Doijen, J. Stroobants, B. Provinciael, S. Noppen, D. Schols, A. Stevaert, K. Vermeire

This paper demonstrates the use of cellular electrical impedance to monitor SARS-CoV-2 spike-mediated cell-cell fusion and assess fusion inhibitors and spike mutants.

bioRxiv · Dec 13, 2022Microbiology

Structural insights into TRAP association with ribosome-Sec61 complex, and translocon inhibition by a CADA derivative

E. Pauwels, N. R. Shewakramani, B. De Wijngaert, A. Camps, B. Provinciael, J. Stroobants, K.-U. Kalies, E. Hartmann, P. Maes, K. Vermeire, K. Das

The paper presents cryo-EM structures of the ribosome-Sec61 complex with TRAP and CK147, showing TRAP's binding and CK147's inhibition mechanism.

bioRxiv · Sep 28, 2022Cell Biology

Development and optimization of biologically contained Marburg virus for high-throughput antiviral screening

B. Vanmechelen, J. Stroobants, W. Chiu, L. Naesens, J. Schepers, K. Vermeire, P. Maes

This paper develops a biologically contained Marburg virus system for high-throughput antiviral screening and validates its safety and utility.

bioRxiv · Jul 29, 2022Microbiology

Carbohydrate-Binding Protein from Stinging Nettle as Fusion Inhibitor for SARS-CoV-2 Variants of Concern

E. Vanhulle, T. D'huys, B. Provinciael, J. Stroobants, A. Camps, S. Noppen, D. Schols, E. J. M. Van Damme, P. Maes, A. Stevaert, K. Vermeire

This paper shows that UDA, a protein from stinging nettle, inhibits SARS-CoV-2 and its variants by blocking viral entry and fusion, with nanomolar potency.

bioRxiv · Jul 8, 2022Microbiology

SARS-CoV-2 Permissive Glioblastoma Cell Line for High Throughput Antiviral Screening

E. Vanhulle, J. Stroobants, B. Provinciael, A. Camps, S. Noppen, P. Maes, K. Vermeire

This paper develops a SARS-CoV-2 permissive glioblastoma cell line for high-throughput antiviral screening, showing it supports viral replication and provides reliable IC50 values for antivirals.

bioRxiv · Feb 13, 2022Microbiology

Intracellular flow cytometry complements RT-qPCR detection of circulating SARS-CoV-2 variants of concern

E. Vanhulle, B. Provinciael, J. Stroobants, A. Camps, P. Maes, K. Vermeire

This paper introduces a flow cytometry method to detect and differentiate SARS-CoV-2 infected cells at single-cell level, complementing RT-qPCR for variant detection.

bioRxiv · Feb 2, 2022Microbiology

Identification of novel Ebola virus inhibitors using biologically contained virus

B. Vanmechelen, J. Stroobants, W. Chiu, J. Schepers, A. Marchand, P. Chaltin, K. Vermeire, P. Maes

This study screens over 4,200 small-molecule compounds against biologically contained Ebola virus to identify novel inhibitors.

bioRxiv · Dec 9, 2021Microbiology

Development and optimization of a novel T7 polymerase-independent Marburg virus minigenome system

B. Vanmechelen, J. Stroobants, K. Vermeire, P. Maes

The paper develops a T7 polymerase-independent MARV minigenome system using native RNA polymerase II, showing improved performance in difficult cell lines and enabling high-throughput screening.

Antiviral Research · Jan 1, 2021Peer-reviewedMicrobiology