Author

B. E. Housden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:Drosophila· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

N. Perrimon· 2 shared Y. Wang· 2 shared A. E. Housden· 1 shared A. J. Valvezan· 1 shared A. Sharma· 1 shared B. D. Manning· 1 shared B. H. Jenkins· 1 shared C. Kelley· 1 shared

Activity by Year

2017-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCancer Biology

N. Perrimon

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Author profile →

3 papers

Recent·Most cited

Inhibition of autophagy as a novel therapy for the treatment of neurofibromatosis type 1 tumors

M. Stevens, Y. Wang, S. J. Bouley, T. R. Mandigo, A. Sharma, S. Sengupta, A. E. Housden, S. Oltean, N. Perrimon, J. A. Walker, B. E. Housden

This study identifies autophagy inhibitors as potential therapies for NF1 tumors by showing their effectiveness in Drosophila and human models.

bioRxiv · Dec 20, 2021Cancer Biology

Emergent RNA-RNA interactions can promote stability in a nascent phototrophic endosymbiosis

B. H. Jenkins, F. Maguire, G. Leonard, J. D. Eaton, S. West, B. E. Housden, D. S. Milner, T. A. Richards

The paper demonstrates that RNA-RNA interactions mediated by host RNAi can impose a cost on host growth when endosymbionts are digested, promoting stability in a nascent eukaryote-eukaryote endosymbiosis.

bioRxiv · Apr 11, 2021Evolutionary Biology

Variable dose analysis: A novel RNAi-based method for detection of synthetic lethal interactions

B. E. Housden, Z. Li, C. Kelley, Y. Wang, Y. Hu, A. J. Valvezan, B. D. Manning, N. Perrimon

This paper introduces a novel RNAi-based method called variable dose analysis (VDA) to detect synthetic lethal interactions, identifying four FDA-approved drugs for TSC-related tumors.

bioRxiv · Aug 16, 2017Cancer Biology