N. Perrimon

Two antagonistic gene regulatory networks drive Arabidopsis root hair growth at low temperature

This paper identifies two opposing gene regulatory networks that control root hair growth in Arabidopsis at low temperature, revealing their role in integrating environmental and internal signals.

Insect hormone PTTH regulates lifespan through temporal and spatial activation of NF-κB signaling during metamorphosis

This study shows that PTTH loss-of-function in Drosophila extends lifespan by repressing NF-κB signaling in oenocytes during metamorphosis.

Tick hemocytes have pleiotropic roles in microbial infection and arthropod fitness

This study identifies hemocyte heterogeneity and pleiotropic roles in ticks using multi-omics approaches, revealing their impact on immunity, metabolism, and arthropod fitness.

An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway

The paper identifies a nutrient sensor in Drosophila that integrates into the mTORC1 pathway to respond to methionine availability, revealing an evolutionary mechanism for expanding nutrient sensing capabilities.

Mechanistic characterization of a Drosophila model of paraneoplastic nephrotic syndrome

This study identifies a mechanism by which gut tumors in Drosophila induce kidney dysfunction through Pvf1-mediated signaling.

Next-generation large-scale binary protein interaction network for Drosophila

The paper generates a high-confidence binary protein interaction network for Drosophila using yeast two-hybrid screens and integrates it with existing data to create a comprehensive reference network.

Continuous muscle, glial, epithelial, neuronal, and hemocyte cell lines for Drosophila research

The paper generates continuous cell lines for Drosophila muscle, glial, epithelial, neuronal, and hemocyte types using RasV12 activation and ecdysone differentiation.

A genetic model for in vivo proximity labeling of the mammalian secretome

This paper introduces a genetic mouse model for in vivo proximity labeling of the secretome, revealing organ-specific secretory profiles and serum trafficking.

Inhibition of autophagy as a novel therapy for the treatment of neurofibromatosis type 1 tumors

This study identifies autophagy inhibitors as potential therapies for NF1 tumors by showing their effectiveness in Drosophila and human models.

REPTOR/CREBRF encode key regulators of muscle energy metabolism

This study identifies REPTOR/CREBRF as key regulators of muscle energy metabolism, showing they repress glycolysis and promote oxidative phosphorylation in both flies and mammals.

Horizontal Transfer of Histone H3 by Mammalian Cells

The authors withdrew their manuscript due to irreproducible and non-robust results regarding histone H3 horizontal transfer.

Proteomics of protein trafficking by in vivo tissue-specific labeling

The paper develops an in vivo platform to study secreted protein trafficking between organs, identifies interorgan communication factors, and finds conserved adipokines affecting muscle activity.

A Drosophila model of oral peptide therapeutics for adult intestinal stem cell tumors

This paper evaluates the efficacy of a TONDU peptide in suppressing Yki-driven intestinal stem cell tumors in Drosophila by inhibiting YAP-TEAD interaction and modulating integrin signaling.

A single-cell survey of Drosophila blood

This study uses scRNA-seq to analyze Drosophila hemocytes under inflammatory conditions, revealing new states and a role for FGF signaling in immune responses.

The RhoGEF Cysts couples apical polarity proteins to Rho and myosin activity at adherens junctions

This study identifies Cysts as a key regulator linking apical polarity proteins to Rho1 and myosin activity at adherens junctions in Drosophila.

Conserved phosphorylation hotspots in eukaryotic protein domain families

The paper identifies conserved phosphorylation hotspots across 40 eukaryotic species and shows their functional importance in protein domains.

Directed evolution of TurboID for efficient proximity labeling in living cells and organisms

The paper develops TurboID and miniTurbo, biotin ligase mutants with enhanced catalytic efficiency for proximity labeling in cells and organisms, significantly reducing labeling time and toxicity.

Variable dose analysis: A novel RNAi-based method for detection of synthetic lethal interactions

This paper introduces a novel RNAi-based method called variable dose analysis (VDA) to detect synthetic lethal interactions, identifying four FDA-approved drugs for TSC-related tumors.

TOWARDS COORDINATED INTERNATIONAL SUPPORT OF CORE DATA RESOURCES FOR THE LIFE SCIENCES

The paper discusses the need for coordinated international funding to sustain core data resources in life sciences and presents considerations for a new funding model.