SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway
D.-Y. Chen, N. Khan, B. J. Close, R. K. Goel, B. Blum, A. H. Tavares, D. Kenney, H. L. Conway, J. K. Ewoldt, S. Kapell, V. C. Chitalia, N. A. Crossland, C. S. Chen, D. N. Kotton, S. C. Baker, , M. Saeed
This study identifies SARS-CoV-2 inhibition of the JAK-STAT pathway as a mechanism to suppress interferon signaling across diverse cell types.
bioRxiv · Oct 27, 2020 · PreprintMicrobiology