L. A. Cavacini

Single-domain antibodies reveal unique borreliacidal epitopes on the Lyme disease vaccine antigen, Outer surface protein A (OspA)

The paper identifies unique borreliacidal epitopes on OspA using VHHs and evaluates their reactivity across OspA serotypes.

Structural Elucidation of a Protective B cell Epitope on Outer Surface Protein C (OspC) of the Lyme disease spirochete, Borreliella burgdorferi

This paper determines the crystal structure of a protective B cell epitope on OspC, revealing its quaternary nature and informing vaccine design for Lyme disease.

Oral administration of a single anti-CfaE nanobody provides broadly cross-protective immunity against major pathogenic Enterotoxigenic Escherichia coli strains

This study shows that oral administration of a single nanobody provides broad protection against multiple ETEC strains by targeting conserved epitopes.

IgA MAb blocks SARS-CoV-2 Spike-ACE2 interaction providing mucosal immunity

This study identifies an IgA monoclonal antibody that blocks SARS-CoV-2 Spike-ACE2 interaction and provides mucosal immunity.

Oral administration of an anti-CfaE secretory IgA antibody protects against Enterotoxigenic Escherichia coli diarrheal disease in a non-human primate model

This study evaluates the efficacy of secretory IgA2 and dimeric IgA2 antibodies against ETEC in a non-human primate model, finding that oral SIgA2 significantly reduced diarrheal attack rates.