Author

S. C. Baker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 3 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. H. Tavares· 2 shared D. Kenney· 2 shared D. N. Kotton· 2 shared D.-Y. Chen· 2 shared F. Douam· 2 shared H. L. Conway· 2 shared J. H. Connor· 2 shared M. Saeed· 2 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

A. H. Tavares

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1Omicron

D.-Y. Chen, D. Kenney, C.-V. Chin, A. H. Tavares, N. Khan, H. L. Conway, G. Liu, M. C. Choudhary, H. P. Gertje, A. K. O'Connell, D. N. Kotton, A. Herrmann, A. Ensser, J. H. Connor, M. Bosmann, , M. Saeed

This study compares the pathogenicity and immune evasion of an Omicron S-bearing virus with natural Omicron, showing vaccine escape via S mutations but severe disease due to factors outside S.

bioRxiv · Oct 13, 2022 · PreprintMicrobiology

BK polyomavirus (BKPyV) is a risk factor for bladder cancer through induction of APOBEC3-mediated genomic damage

S. C. Baker, A. S. Mason, R. G. Slip, K. T. Skinner, A. Macdonald, O. Masood, R. S. Harris, T. R. Fenton, M. Periyasamy, S. Ali, J. Southgate

This study shows BKPyV infection increases APOBEC3-mediated genomic damage in urothelial cells, contributing to bladder cancer risk in immunocompromised individuals.

bioRxiv · May 13, 2021Cancer Biology

SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway

D.-Y. Chen, N. Khan, B. J. Close, R. K. Goel, B. Blum, A. H. Tavares, D. Kenney, H. L. Conway, J. K. Ewoldt, S. Kapell, V. C. Chitalia, N. A. Crossland, C. S. Chen, D. N. Kotton, S. C. Baker, , M. Saeed

This study identifies SARS-CoV-2 inhibition of the JAK-STAT pathway as a mechanism to suppress interferon signaling across diverse cell types.

bioRxiv · Oct 27, 2020 · PreprintMicrobiology

Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro

N. Drayman, K. A. Jones, S.-A. Azizi, H. M. Froggatt, K. Tan, N. Ivanova Maltseva, S. Chen, V. Nicolaescu, S. Dvorkin, K. Furlong, R. S. Kathayat, M. R. Firpo, V. Mastrodomenico, E. A. Bruce, M. M. Schmidt, , S. Tay

The paper screens 1,900 drugs to find inhibitors of SARS-CoV-2 replication, identifies masitinib as a 3CLpro inhibitor effective in vitro, and shows its broad anti-viral activity.

bioRxiv · Aug 31, 2020Microbiology

Structure-Guided Mutagenesis Alters Deubiquitinating Activity 2 and Attenuates Pathogenesis of a Murine Coronavirus

X. Deng, Y. Chen, A. M. Mielech, M. Hackbart, K. R. Kesely, R. C. Mettelman, A. OBrien, M. E. Chapman, A. D. Mesecar, S. C. Baker

This study uses structure-guided mutagenesis to identify PLP2 DUB activity as an interferon antagonist in murine coronavirus pathogenesis.

Journal of Virology · May 18, 2020Peer-reviewedMicrobiology