Author

B. A. Osuna

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:bacteria (other)· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:protein folding & dynamics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

J. Bondy-Denomy· 3 shared A. Frost· 1 shared A. L. Borges· 1 shared A. R. Davidson· 1 shared B. Garcia· 1 shared B. J. Rauch· 1 shared B. P. Kleinstiver· 1 shared B. Wiedenheft· 1 shared

Activity by Year

2018-2019 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersMicrobiology

J. Bondy-Denomy

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Listeria phages induce Cas9 degradation to protect lysogenic genomes

B. A. Osuna, S. Karambelkar, C. Mahendra, K. A. Christie, B. Garcia, A. R. Davidson, B. P. Kleinstiver, S. Kilcher, J. Bondy-Denomy

This study identifies AcrIIA1 as a phage-encoded protein that inhibits Cas9 in Listeria monocytogenes by promoting its degradation, protecting lysogenic genomes.

bioRxiv · Sep 30, 2019Microbiology

Temperature-responsive competitive inhibition of CRISPR-Cas9

F. Jiang, J.-J. Liu, B. A. Osuna, M. Xu, J. D. Berry, B. J. Rauch, E. Nogales, J. Bondy-Denomy, J. A. Doudna

This study shows AcrIIA2 and AcrIIA2b inhibit Cas9 DNA binding through structural occlusion, with temperature-dependent effects due to structural and environmental differences.

bioRxiv · Sep 3, 2018Biochemistry

Vms1p is a release factor for the Ribosome-associated Quality control Complex

O. Z. Rendon, E. K. Fredrickson, C. J. Howard, J. V. Vranken, S. Fogarty, N. D. Tolley, R. Kalia, B. A. Osuna, P. S. Shen, C. P. Hill, A. Frost, J. Rutter

This study identifies Vms1p as the tRNA hydrolase that releases nascent polypeptides in the RQC pathway for degradation.

bioRxiv · Apr 14, 2018Biochemistry

Bacteriophage cooperation suppresses CRISPR-Cas3 and Cas9 immunity

A. L. Borges, J. Y. Zhang, M. Rollins, B. A. Osuna, B. Wiedenheft, J. Bondy-Denomy

The paper shows that phages cooperate by sharing anti-CRISPR proteins to suppress bacterial CRISPR-Cas immunity, enabling successful infection when individual phages fail to replicate.

bioRxiv · Mar 10, 2018Microbiology