Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
W. Sun, E. P. Hughes, H. Kim, J. Perovanovic, K. R. Charley, B. Perkins, J. Du, A. Ibarra, A. R. Syage, J. S. Hale, M. A. Williams, D. Tantin
This study shows that OCA-B expression promotes CD4+ T cell memory and identifies memory precursor cells using a reporter mouse line.
Proceedings of the National Academy of Sciences · Feb 27, 2024Peer-reviewedImmunology
L. M. Sircy, A. G. Ramstead, H. Joshi, A. Baessler, I. Mena, A. Garcia-Sastre, M. A. Williams, J. S. Hale
This study shows that heterologous immunization primes antigen-specific memory CD4 T cells, enhancing early germinal center response but not antibody generation in influenza infection.
bioRxiv · Aug 29, 2023Immunology
O. Jensen, S. Trivedi, K. Li, J. Aube, J. S. Hale, E. T. Ryan, D. T. Leung
This study tests 5-OP-RU as a mucosal adjuvant in a murine cholera vaccine model, showing increased MAIT cell expansion but limited antibody response improvements.
bioRxiv · Jun 17, 2022Immunology
O. Jensen, S. Trivedi, J. D. Meier, K. Fairfax, J. S. Hale, D. T. Leung
The paper identifies and characterizes a novel subset of T follicular helper-like MAIT cells that can provide B cell help and promote IgA antibody production in mucosal immunity.
bioRxiv · Oct 5, 2020 · PreprintImmunology
S. Trivedi, D. Labuz, C. P. Anderson, C. V. Araujo, A. Blair, E. Middleton, A. Tran, M. Mulvey, R. Campbell, J. S. Hale, M. T. Rondina, D. T. Leung
This study shows MAIT cells are activated and dysfunctional in sepsis, contributing to protective cytokine responses in experimental sepsis but reduced in clinical cases.
bioRxiv · Feb 5, 2020Physiology
J. S. Hale, A. Jimenez-Pascual, A. Kordowski, J. Pugh, S. Rao, D. J. Silver, T. Alban, D. B. Watson, R. Chen, T. M. McIntyre, G. Colombo, G. Taraboletti, K. O. Holmberg, K. Forsberg-Nilsson, J. D. Lathia, F. Siebzehnrubl
This study identifies a novel signaling loop involving ADAMDEC1 and FGF2/FGFR1 that maintains glioblastoma cancer stem cells and shows targeting this loop reduces tumor growth.
bioRxiv · Jan 26, 2019Cancer Biology
T. J. Alban, A. G. Alvarado, M. D. Sorensen, D. Bayik, J. Volovetz, E. Serbinowski, E. Mulkearns-Hubert, M. Sinyuk, J. S. Hale, G. R. Onzi, M. McGraw, P. Huang, M. M. Grabowski, C. A. Wathen, T. Radivoyevitch, , J. D. Lathia
The paper identifies immune-suppression signatures in glioblastoma (GBM) patients, showing elevated myeloid-derived suppressor cells (MDSCs) linked to poor prognosis and reduced survival.
JCI Insight · Nov 2, 2018Peer-reviewedCancer Biology
E. E. Mulkearns-Hubert, L. A. Torre-Healy, D. J. Silver, J. T. Eurich, E. Serbinowski, M. Hitomi, J. Zhou, B. Przychodzen, R. Zhang, S. A. Sprowls, J. S. Hale, T. Alban, A. Berezovsky, B. A. Bell, P. R. Lockman, , J. D. Lathia
This study identifies clofazimine as a Cx46 inhibitor that targets glioblastoma cancer stem cells by disrupting gap junction communication, enhancing the efficacy of temozolomide.
bioRxiv · Mar 26, 2018Cancer Biology
C. Saygin, A. Wiechert, V. S. Rao, R. Alluru, E. Connor, P. S. Thiagarajan, J. S. Hale, Y. Li, A. Chumakova, A. Jarrar, Y. Parker, D. J. Lindner, A. B. Nagaraj, J. J. Kim, A. DiFeo, , O. Reizes
This study identifies CD55 as a signaling hub that regulates self-renewal and cisplatin resistance in endometrioid tumors through distinct signaling pathways.
bioRxiv · Jun 27, 2017Cancer Biology