B. Maier

Antigenic variation impacts gonococcal lifestyle and antibiotic tolerance by modulating interbacterial forces

This study shows that pilin antigenic variation in Neisseria gonorrhoeae alters T4P filament structure, affecting bacterial lifestyle and antibiotic tolerance by changing interbacterial forces.

Collective polarization dynamics in gonococcal colonies

This study reveals a transition from uncorrelated to collective membrane polarization dynamics in Neisseria gonorrhoeae colonies, linked to oxygen gradients and antibiotic tolerance.

A neutrophil-B-cell axis governs disease tolerance during sepsis via Cxcr4

This study identifies a neutrophil-B-cell axis that promotes disease tolerance during sepsis through Cxcr4 activation, reducing organ damage and immunothrombosis.

Translation rescue by targeting Ppp1r15a upstream open reading frame in vivo

This study shows that targeting the Ppp1r15a upstream open reading frame rescues translation and improves kidney function in sepsis by overcoming uORF-mediated repression.

Spatio-temporal dynamics of growth and death within spherical bacterial colonies

The paper develops methods to measure growth rates in bacterial colonies and finds that Neisseria gonorrhoeae forms steep growth rate gradients and uses stringent response to protect against stress.

Antibiotics modulate attractive interactions in bacterial colonies affecting survivability under combined treatment

Susceptibility rhythm to bacterial endotoxin in myeloid clock-knockout mice

The paper shows that myeloid clocks are not required for circadian rhythms in cytokine responses or immune cell trafficking after LPS challenge, suggesting systemic cues drive these responses.

Human Microbial Transplant Restores T Cell Cytotoxicity and Anti-Tumor Response to PD-L1 Blockade in Gnotobiotic Mice

The paper shows that human microbial transplants can restore T cell cytotoxicity and anti-tumor response to PD-L1 blockade in gnotobiotic mice by altering immune cell infiltration and gene expression.

CITEseq analysis of non-small-cell lung cancer lesions reveals an axis of immune cell activation associated with tumor antigen load and TP53 mutations

The paper analyzes CITEseq data from NSCLC lesions to identify an immune cell activation module linked to tumor antigen load and TP53 mutations.

Open Source ImmGen: network perspective on metabolic diversity among mononuclear phagocytes

The paper analyzes metabolic diversity in mononuclear phagocytes across tissues using integrated datasets and a network-based approach, identifying key metabolic subnetworks and their functional roles.

Adaptive evolution of hybrid bacteria by horizontal gene transfer

This study shows that horizontal gene transfer rapidly generates adaptive hybrid bacteria with genomic and functional changes in a parallel evolution experiment.

Motor properties of PilT-independent type 4 pilus retraction in gonococci

This study shows gonococcal type 4 pili can retract without PilT, but with reduced force and speed, suggesting PilT is not essential but contributes to high-force functions.

Type IV pilin post-translational modifications modulate materials properties of bacterial colonies

This study investigates how post-translational modifications of pilin subunits in Neisseria gonorrhoeae affect microcolony shape and dynamics by altering attractive forces and material properties.