Author

A. O. Kamphorst

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:flow cytometry· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2

Frequent Co-Authors

E. Humblin· 2 shared S. Kim-Schulze· 2 shared T. Dawson· 2 shared A. Charap· 1 shared A. M. Farkas· 1 shared A. Magen· 1 shared A. Soares-Schanoski· 1 shared A. Tabachnikova· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersImmunology

E. Humblin

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Functional impairment of "helpless" CD8+ memory T cells is transient and driven by prolonged but finite cognate antigen presentation

V. van der Heide, B. Davenport, B. Cubitt, V. Roudko, D. Choo, E. Humblin, K. Jhun, K. Angeliadis, T. Dawson, G. Furtado, A. O. Kamphorst, R. Ahmed, J. C. de la Torre, D. Homann

This study shows that helpless CD8+ memory T cells, which form without CD4+ help, have transient functional impairments due to prolonged antigen exposure, which resolve over time.

bioRxiv · Jan 22, 2024Immunology

Intratumoral mregDC and CXCL13 T helper niches enable local differentiation of CD8 T cells following PD-1 blockade

A. Magen, P. Hamon, N. Fiaschi, L. Troncoso, E. Humblin, D. D'souza, T. Dawson, M. D. Park, J. Kim, S. Hamel, M. Buckup, C. Chang, A. Tabachnikova, H. Schwartz, N. Malissen, , Merad

The paper identifies intratumoral niches involving mregDC and CXCL13+ Th cells that support CD8 T cell differentiation following PD-1 blockade in HCC patients.

bioRxiv · Jun 22, 2022 · PreprintImmunology

NKG2A and HLA-E define a novel alternative immune checkpoint axis in bladder cancer

B. Salome, J. P. Sfakianos, J. Daza, A. Charap, C. Hammer, R. Banchereau, A. M. Farkas, D. Geanon, G. Kelly, R. M. de Real, B. Lee, K. G. Beaumont, S. Shroff, Y. S. A. Wang, Y.-C. Wang, , Mariath

This study identifies NKG2A and HLA-E as an alternative immune checkpoint axis in bladder cancer, showing NKG2A+ CD8 T cells can bypass HLA-ABC loss through TCR-independent cytotoxicity.

bioRxiv · Mar 4, 2022 · PreprintImmunology

Human Microbial Transplant Restores T Cell Cytotoxicity and Anti-Tumor Response to PD-L1 Blockade in Gnotobiotic Mice

J. N. Borgerding, J. Shang, G. J. Britton, H. Salmon, C. Bigenwald, B. Maier, S. R. Rose, I. J. Mogno, A. O. Kamphorst, M. Merad, J. J. Faith

The paper shows that human microbial transplants can restore T cell cytotoxicity and anti-tumor response to PD-L1 blockade in gnotobiotic mice by altering immune cell infiltration and gene expression.

bioRxiv · Aug 7, 2020 · PreprintImmunology