F. Oakley

Compromised chronic efficacy of a Glucokinase Activator AZD1656 in mouse models for common human GCKR variants

This study shows that GKRP deficiency in mouse models reduces the long-term efficacy of the GKA AZD1656 and increases liver lipid accumulation.

UCHL1-dependent control of Hypoxia-Inducible Factor Transcriptional Activity in Liver Disease.

This study shows that UCHL1 regulates HIF1 activity in liver fibrosis by cleaving ubiquitin chains, increasing HIF1 levels, and promoting fibrosis.

A neutrophil-B-cell axis governs disease tolerance during sepsis via Cxcr4

This study identifies a neutrophil-B-cell axis that promotes disease tolerance during sepsis through Cxcr4 activation, reducing organ damage and immunothrombosis.

The E3 ligase RNF115 regulates phagosome maturation and host response to bacterial infection

This study identifies RNF115 as an E3 ligase that regulates phagosomal maturation and host response to bacterial infection through ubiquitylation.

mTORC1-Plin3 pathway is essential to activate lipophagy and protects against hepatosteatosis.

This study identifies the mTORC1-Plin3 pathway as essential for lipophagy, which protects against hepatosteatosis by promoting lipid droplet degradation.

Loss of ELK1 has differential effects on age-dependent organ fibrosis and integrin expression

This study shows that loss of ELK1 leads to age-related fibrosis in the lung and liver but not heart or kidneys, and links reduced ELK1 to cigarette smoke exposure.

Regulation of checkpoint kinase signalling and tumorigenesis by the NF-κB regulated gene, CLSPN

This study shows that CLSPN, regulated by NF-κB, influences checkpoint kinase signalling and tumorigenesis, with implications for cancer treatment resistance and biomarker potential.

A novel bioreactor technology for modelling fibrosis in human and rodent precision-cut liver slices.

This paper develops a bioreactor system that extends the viability of precision-cut liver slices (PCLS) to 6 days under normoxic conditions and demonstrates its use in modeling fibrogenesis and testing anti-fibrotic drugs.

Identification of a novel, NF-κB nucleolar stress response pathway

The paper identifies a novel NF-κB nucleolar stress response pathway triggered by PolI complex disruption, showing TIF-IA degradation and therapeutic relevance in colorectal tumors.